Defective T-Cell Apoptosis and T-Regulatory Cell Dysfunction in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic, progressive, systemic autoimmune disease that mostly affects small and large synovial joints.At the molecular level, RA is characterized by a profoundly defective innate and adaptive immune response that results in a chronic state of inflammation.Two of the most significant alterations in T-lymphocyte (T-cell